Holtz is the author of three books about the depiction of medicine on TV: "The Medical Science of House, M.D." (Berkley/Penguin 2006), "The Real Grey's Anatomy" (Berkley/Penguin 2010), and "House, M.D. vs. Reality" (Berkley/Penguin 2011).

Holtz began reporting for CNN in 1980 and was a CNN Medical Correspondent for his last 10 years at the network.

Andrew Holtz was Senior News Anchor and Chief Anchor at MDiTV... a video & social networking health news and information resource for web and mobile devices that had a brief active life (2009-2010). Many of the video reports are still online.

Holtz is a charter member of the Association of Health Care Journalists. He served on the board of directors from 2000-2011, including four years as Board President. He served as Interim Executive Director in 2004-2005.